I think I can understand where you coming from.
I used drug for years for the purpose of spiritual exploration.
I nearly killed myself with drug and had a near death due to overdose as well.
Since I was 4 years old, I knew something was wrong with this world.
One day, I was looking at people from the hill in the town where I lived and something strange hit me about the scene that I was seeing.
I couldn't pin point it but later, I came to realize that what I experience was the glimpse into the nature of this world which is one big jail.
From teenagers till mid 30's, I did search all over the place looking for the map for the ultimate knowledge.
Not just drugs but I studied religions and magic(k) systems of various sorts.
And it is almost miracle that I found genuine map/activation code/master code/ DHAMMA since my Sila was very weak.
Some people found Dhamma by the strength of the accumulated Sila through many re-births and some peole found it from the strength of the accumulated Samadhi through many re-births.
In my case, the main factor was my sincere dedication to the ultimate knowledge that has been something extremely strong in me through many re-births.
But I can totally symphasize with the people who are willing to do drugs for the pursue of spiritual knowledge/advancement.
However, as a person who did pursue the path to the extreme, if I may add, in all honesty, it does not bring the true knowledge.
Mind you, there have been many people, who somewhat glimpsed into the fraction of the reality.
And sometimes drug can generate some penetration into certain fraction of it.
However, there have been no one, no system, no activation code that actually penetrated the entire axis of reality with or without drugs.
Many seekers went through terrible ordeals in pursue of the master knowledge and sometime they glimpsed into the fraction of the reality.
Speaking of fraction of the reality, it's like they witnessed a portion/slice of the onion and thinking they saw it all.
However, Samsara is not your average onion.
It's multi-layered (not in the physical sense, though) upon multi-layered.
Every single one of the seekers including Jesus, Percival, anonymous Gnostics and etc. only witnessed certain slice/portion of the super mega-onion that is impossible to fathom.
To sum it up, all the drug in the world cannot give you what you want.
(Along with all the religions/magic(k) systems as well)
But you do have the master code that was expounded well by the knowledge master, the Buddha.
And regarding isolation, unfortunately, it' almost impossible to avoid.
When one takes up the practice of Dhamma sincerely, it truly goes against the stream of the world.
If you live in the West, most likely, you won't find a sincere fellow Dhamma practicer.
I lost many friends when I gave up drinking, partying, meat eating, womanizing, and etc.
However, I came into complete isolation when I began the Dhamma practice seriously.
I am surrounded by the Christians / non-religious hedonists and nobody that I know accept a practicing Buddhist, let alone the strictest orthodox Buddhist like myself.
Should one be depressed with this situation?
What is going with the situation is, whenever a seeker take up the Dhamma practice with serious determination, all the problems and all the minions of Mara seem to be jumping onto the seeker to present endless challenges.
When a seeker overcame one problem/kilesa, the other will follow and sometimes multiple attacks will occur at once.
However, that means, from wider perspective, you do pose serious threat to Mara.
More gut wrenching battle means you are getting closer to 'BREAK OUT' point.
'Break out' that requires to pass through the each levels of awakening.
Mara does not enjoy somebody making serious efforts to break out from the jail/enter the stream/sailing towards to the other shore.
And of course it's going to be difficult and painful because we are the one who are attempting JAILBREAK from Samsara!
If you are isolated, if you feel pain due to the genuine & sincere practice of Dhamma, that is something to be celebrated.
The Awakened One recommended solitude/isolation if one cannot find a fellow spiritual friend.
Nobody crossed the flood (Samsara) by enjoying entertainments.
Nobody encountered the Deathless element by indulging in Samsara.
Every seekers' journey is a solitary battle.
The Buddha and Arahant disciples were fought the solitary battle and roared the lions roar in solitude.
We are no exception.
If one wants liberation, one must take up the battle.
No matter how you cut it, Dhamma practice is the battle that goes against the stream of the world, directly toward to the other shore.
The very good news is, at least now we have a system/activation code/genuine map/ that actually works.
Dhamma is THE only system that works.
I hope you be careful/stay away from drugs and save many years so you can get into the stream as soon as possible.
There's no security in any of Samaric existence.
This life might be your last chance to practice genuine Dhamma before it'd disappear for Aeon.
Again, nothing is more important than entering the stream.
It's worth enduring isolation and difficulties to enter the stream.