According to scientist, this universe is made of energy and space.
According to others, this universe is made of 5 elements + consciousness.
According to others, this universe is made of X, Y, Z, etc.
Regardless, how many things you want to say, at the end, you will come to the conclusion that those nature of bla, bla, bla is simply like mist.
For you this "mist" is said as bla, bla, bla.
But, what is the point to be happy with that bla, bla, bla, when inside that bla, bla, bla is baseless and rootless?
5 elements are just concept.
As long as, you cannot find 5 inherent things, they are just concept - a label on top of the cloud.
This universe is made of mickey mouse, donald duck, human, fish, water, etc.
Yes, you can category this universe as much as you wish as A to Z.
But, when you really ask: I really want to find out the inherent thing that make the universe.
What kind of answer can you get?
Not even 5 elements. Because these 5 elements are simply concept, like Mickey Mouse, and Donald Duck.
Scientiest try to find the inherent nature that form this universe. Until now, they still cannot find. What they say today, is different with what they say in the past and will be different again in the future.
Why? Because they never ever find the answer that can consist of inherent existent elements.
They can waste their time in that searching, at the end they will get nothing satisfied.
It is like someone who try to find the trace of birds flying in the sky.
Until aeons, you won't find it.
Looking for something impossible. It is not we do not have the ability to find. But it is because the nature itself doesn't have what you are looking for and it just cannot have it.
If this nature has inherent existence, without doubt you will find the answer soon or later.
But, if this nature has no inherent existence, without doubt you will fail.
No point to find the trace of birds in the sky.
The answer is obvious - NO SUBSTANCE for the mysterious substances you are looking for.
I am not here nor there.
I am not right nor wrong.
I do not exist neither non-exist.
I am not I nor non-I.
I am not in samsara nor nirvana.
To All Buddhas, I bow down for the teaching of emptiness. Thank You!