Its said that without the Paramita of Wisdom, the other five perfections will be lacking and will be unable to be truly transcendent actions. The Paramita of Wisdom is inseparable from the Five Wisdoms, since if you don't have the latter, you won't have the former (Perfection of Wisdom). Furthermore all Five Wisdoms relate individually to each transcendent perfection. For example, the Perfection of Generosity could be hindered by any of the five poisons, such as anger, desire, ignorance, jealousy or pride. The ability to transmute that poison into one of the Wisdoms would allow ones Generosity to act without these stains.