Chapter 12 of Mulamadhyamika made an explicit use of the chatuskoti to refute the inherent existence of suffering. To be exact, verse 1 of chapter 12:
Some assert that anguish arises from being made by self, made by other, by both, without cause. To do that is not suitable.
Then Nagarjuna continues to refute each of these cases. The commentary by Pingala, Buddhapalita, and Chandrakirti are quite extensive, which i shall not quote here.
Hope it helps!
Homage to the Mother of Buddhas as well as of the groups of Hearers and Bodhisattvas
which through knowledge of all leads Hearers seeking pacification to thorough peace
And which through knowledge of paths causes those helping transmigrators to achieve the welfare of the world,
And through possession of which the Subduers set forth these varieties endowed with all aspects.
- Ornament of Clear Realisation