Heck, as I recall when I was in high school in the 1970's, there was an issue about transplanting a baboon's heart into a baby. The parents had a religious objection. It seems they subscribed to the belief the soul resided in the heart. My art teacher, who had an off-the-wall sense of humor, remarked that he wondered if they were worried that if they baby died whether it it would go to Baboon Heaven or Baby Hell?
For me these questions are intellectual exercises for the amusement of the cogitator (is that a word?) You have "ethical" questions and pragmatic reality. Like the question of using deadly force to protect yourself and your family. This isn't even a question for me. If some miscreant shocks and awes his way through my front door or back window, he will find three nine millimeter slugs in him before he gets ten feet into my home. Sorry if this shocks any ariyans here; but I would try to stop him rather than kill.
Same for animal/human cloned organs; sorry about the dead swine, but this is one reason the Buddha said it was unfortunate to be born into the animal womb. People like to hunt animals, eat animals, animals eat each other, die from terrible accidents and illness, scientists use them for all kinds of awful experiments (well scientists have and still do use people for awful experiments too). Samsara really is unattractive isn't it? Think I will sit a while. Nibbanna awaits.